Simulation of pH-dependent edge strand rearrangement in human -2 microglobulin
نویسندگان
چکیده
منابع مشابه
Simulation of pH-dependent edge strand rearrangement in human β-2 microglobulin
Amyloidosis results from abnormal aggregation of native or proteolyzed proteins into amyloid fibrils [1] and is associated with an array of maladies, including Alzheimer’s Disease, Parkinson’s Disease, spongiform encephalopathies, type II diabetes and several forms of systemic amyloidosis [2, 3]. In each case, a protein or a proteolyzed fragment aggregates to form unbranched fibrils 10-20 nm wi...
متن کاملSimulation of pH-dependent edge strand rearrangement in human beta-2 microglobulin.
Amyloid fibrils formed from unrelated proteins often share morphological similarities, suggesting common biophysical mechanisms for amyloidogenesis. Biochemical studies of human beta-2 microglobulin (beta2M) have shown that its transition from a water-soluble protein to insoluble aggregates can be triggered by low pH. Additionally, biophysical measurements of beta2M using NMR have identified re...
متن کاملHuman 8 2 - microglobulin is a Substrate
Incubation of purified human 82-microglobulin (B2-m) with tissue transglutaminase (Tgase) resulted in the formation of high molecular weight polymers revealed by sodium dodecyl sulfate polyacrylamide gel electrophoresis. In the presence of 30 mM ['4C]methylamine, the polymer formation was prevented, but incorporation of methylamine into ,8 2-m (equal to 1 methylamine per 1 molecule) could be ob...
متن کاملRegulation of human 2-microglobulin transactivation in hematopoietic cells
http://bloodjournal.hematologylibrary.org/content/101/8/3058.full.html Updated information and services can be found at: (4939 articles) Immunobiology (3094 articles) Hematopoiesis and Stem Cells (1086 articles) Gene Expression Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repub_requests Infor...
متن کاملHuman 8 2 - microglobulin is a Substrate of Tissue
Incubation of purified human 82-microglobulin (B2-m) with tissue transglutaminase (Tgase) resulted in the formation of high molecular weight polymers revealed by sodium dodecyl sulfate polyacrylamide gel electrophoresis. In the presence of 30 mM ['4C]methylamine, the polymer formation was prevented, but incorporation of methylamine into ,8 2-m (equal to 1 methylamine per 1 molecule) could be ob...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Protein Science
سال: 2006
ISSN: 0961-8368,1469-896X
DOI: 10.1110/ps.051814306